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KMID : 0378019750180101297
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New Medical Journal
1975 Volume.18 No. 10 p.1297 ~ p.1302
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A Study on Serum Heat-stable Alkaline Phosphatase in Pregnancy
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Abstract
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Serum alkaline phosphatase is elevated in late pregnancy. The increase of serum alkaline phosphatase in pregnancy is a result of the presence of placental origin enzyme and it shares the heat stability of the placental enzyme.
We have examined the levels of heat-stable (placental) serum alkaline phosphatase in subjects studied to establish a base line for studies relating to placental function in this community, and to evaluate it´s correlation between heat-stability and EDTA-stability. Serum alkaline phosphatase activities were studied in normal male and female, and in maternal during the pregnancy and the puerperium. There is a negligible activity of the heat-stable alkaline phosphatase in males or in nonpregnant females, but it rises to a significantly elevated level in the late pregnancy and to an even higher level in labor.
The level of heat-stable serum alkaline phosphatase in this subjects determined rises from a mean values of 0.3±0.2 King-Armstrong units/100m1. in nonpregnant women to 9.4±5.8 K. A. units/100ml. in women in labor, and it falls slowly after delivery, reaching 52% of the labor level at 5 days postpartum.
On comparing the heat and EDTA-stability of the alkaline phosphatase, 48% heat stability and 55.3% EDTA stability of it total activity are observed.
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